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DEVELOPMENT OF NOVEL NANO-BASED MULTI-EPITOPE VACCINE AGAINST CORONAVIRUS SARS-COV-2 - GENERATION OF HUMANIZED NSG TRANSFER MOUSE MODEL FOR VACCINE TESTING (VacciNanoCor project)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:0 publications

Grant number: Unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    Institut Pasteur International Network (IPIN)

  • Research Location

    N/A

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Disease models

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

We hypothesize that it may be possible to generate protective anti-SARS-CoV-2 immuneresponse in humanized NSG transfer mouse model. This will be achieved by administering to them of lipid-based nanoparticles carrying peptide molecules, comprising dominant immunogenic B and T cell epitopes from coronavirus SARS-CoV-2. The epitopes will be predicted by EpiDOCK server for evaluation of peptide binding to HLA class II proteins.