DEVELOPMENT OF NOVEL NANO-BASED MULTI-EPITOPE VACCINE AGAINST CORONAVIRUS SARS-COV-2 - GENERATION OF HUMANIZED NSG TRANSFER MOUSE MODEL FOR VACCINE TESTING (VacciNanoCor project)
- Funded by Institut Pasteur International Network (IPIN)
- Total publications:240 publications
Grant number: Unknown
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Key facts
Disease
COVID-19Funder
Institut Pasteur International Network (IPIN)Principal Investigator
N/A
Research Location
N/ALead Research Institution
N/AResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Disease models
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
We hypothesize that it may be possible to generate protective anti-SARS-CoV-2 immuneresponse in humanized NSG transfer mouse model. This will be achieved by administering to them of lipid-based nanoparticles carrying peptide molecules, comprising dominant immunogenic B and T cell epitopes from coronavirus SARS-CoV-2. The epitopes will be predicted by EpiDOCK server for evaluation of peptide binding to HLA class II proteins.
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