DEVELOPMENT OF NOVEL NANO-BASED MULTI-EPITOPE VACCINE AGAINST CORONAVIRUS SARS-COV-2 - GENERATION OF HUMANIZED NSG TRANSFER MOUSE MODEL FOR VACCINE TESTING (VacciNanoCor project)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:211 publications

Grant number: Unknown

Grant search

Key facts

  • Disease

    COVID-19
  • Funder

    Institut Pasteur International Network (IPIN)
  • Principle Investigator

    Pending
  • Research Location

    N/A
  • Lead Research Institution

    N/A
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Disease models

  • Special Interest Tags

    Gender

  • Study Subject

    N/A

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

We hypothesize that it may be possible to generate protective anti-SARS-CoV-2 immuneresponse in humanized NSG transfer mouse model. This will be achieved by administering to them of lipid-based nanoparticles carrying peptide molecules, comprising dominant immunogenic B and T cell epitopes from coronavirus SARS-CoV-2. The epitopes will be predicted by EpiDOCK server for evaluation of peptide binding to HLA class II proteins.

Publicationslinked via Europe PMC

Last Updated:38 minutes ago

View all publications at Europe PMC

Medicine Non-Adherence: A New Viewpoint on Adherence Arising from Research Focused on Sub-Saharan Africa.

Genomic Engineering of Oral Keratinocytes to Establish In Vitro Oral Potentially Malignant Disease Models as a Platform for Treatment Investigation.

Microbial Diversity Impacts Non-Protein Amino Acid Production in Cyanobacterial Bloom Cultures Collected from Lake Winnipeg.

Maternal Diet High in Linoleic Acid Alters Offspring Lipids and Hepatic Regulators of Lipid Metabolism in an Adolescent Rat Model.

Effect of Flour Particle Size on the Glycemic Index of Muffins Made from Whole Sorghum, Whole Corn, Brown Rice, Whole Wheat, or Refined Wheat Flours.

Femtosecond Laser Machining of an X-ray Mask in a 500 Micron-Thick Tungsten Sheet.

The Use of Nautical Activities in Formal Education: A Systematic Review.

Assessing the Psychometric Validity of the Epistaxis Severity Score: Internal Consistency and Test-Retest Reliability.