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Evaluating the determinants of coronavirus tropism in 3D models of human pulmonary epithelia (TROPICORO project - TROPIsm of COROnaviruses)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:232 publications

Grant number: Unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    Institut Pasteur International Network (IPIN)

  • Principal Investigator

    N/A

  • Research Location

    N/A

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

This study will compare the tropism of SARS-CoV-2 and more benign human coronaviruses for primary epithelia of the respiratory tract, to determine whether tropism associates with pathogenicity. The research team will use models based on reconstructed human airway epithelia and take advantage of a lung-on-chip technology that mimics the pulmonary alveolae stretch associated with breathing to develop physiologically relevant models of SARS-CoV-2 infection.

Publicationslinked via Europe PMC

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View all publications at Europe PMC

Structural Rearrangement in Cyclic Cu(II) Pyridyltriazole Complexes: Oxidation of Dabco to Oxalate and CO<sub>2</sub> Conversion to Carbonate.

Administration of FOLFIRINOX for Advanced Pancreatic Cancer: Physician Practice Patterns During Early Use.

Living in a Constant State of Fear: Phenomenological Study on Experiences of Women with High-Risk Pregnancy Waiting for Childbirth in Mpumalanga Province, South Africa.

Self-Administration of Meloxicam via Medicated Molasses Lick Blocks May Improve Welfare of Castrated Calves.

Electrocardiographic Assessment of National-Level Triathletes: Sinus Bradycardia and Other Electrocardiographic Abnormalities.

A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.

Calaspargase-Pegol-Mknl Combined with BCL-2 and MCL-1 Inhibition for Acute Myeloid Leukemia.

"Beyond the Finish Line" the Epidemiology of Injury and Illness in Professional Cycling: Insights from a Year-Long Prospective Study.

Enhanced Effect of Patient Room Disinfection Against Carbapenem-Resistant Enterobacter cloacae and Methicillin-Resistant Staphylococcus aureus Using UV-C Irradiation in Conjunction with UV-C Containment Unit.