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Evaluating the determinants of coronavirus tropism in 3D models of human pulmonary epithelia (TROPICORO project - TROPIsm of COROnaviruses)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:244 publications

Grant number: Unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    Institut Pasteur International Network (IPIN)

  • Principal Investigator

    .

  • Research Location

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

This study will compare the tropism of SARS-CoV-2 and more benign human coronaviruses for primary epithelia of the respiratory tract, to determine whether tropism associates with pathogenicity. The research team will use models based on reconstructed human airway epithelia and take advantage of a lung-on-chip technology that mimics the pulmonary alveolae stretch associated with breathing to develop physiologically relevant models of SARS-CoV-2 infection.

Publicationslinked via Europe PMC

Last Updated:3 days ago

View all publications at Europe PMC

IS<i>Apl4</i>, a New IS<i>1595</i> Family Insertion Sequence Forming a Novel Pseudo-Compound Transposon That Confers Antimicrobial Multidrug Resistance in <i>Actinobacillus pleuropneumoniae</i>.

Living with Dysphagia and Dysarthria: A Qualitative Exploration of the Perspectives of People with Motor Neuron Disease and Their Caregivers.

Delivering the Parenting for Lifelong Health Programme with Parents of Young Children in Wales.

Fluctuations of viti- and oleiculture traditions in the Bronze and Iron Age Levant.

Dysregulated Alternative Splicing in Breast Cancer Subtypes of RIF1 and Other Transcripts.

Elucidating directed neural dynamics of scene construction across memory and imagination

Development and Validation of the Intimate Partner Violence Workplace Disruptions Assessment (IPV-WDA).

Implementing a Novel Resident-Led Peer Support Program for Emergency Medicine Resident Physicians.

Cross-Activity Analysis of CRISPR/Cas9 Editing in Gene Families of <i>Solanum lycopersicum</i> Detected by Long-Read Sequencing.