INVESTIGATING THE ROLE OF APICO-BASAL PROTEINS DURING SARS-COV2 INFECTION (EPIC project)

Key facts

Disease
COVID-19
Funder
Institut Pasteur International Network (IPIN)
Principal Investigator
N/A
Research Location
N/A
Lead Research Institution
N/A
Research Priority Alignment
N/A

Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable

Abstract

Manipulation of the apico-basal Polarity pathways during infection is a strategy routinely used by numerous viruses. This leads to the mislocalization or degradation of the polarity proteins and participate to the disruption of the epithelial integrity. Nothing is known so far concerning SARS-CoV2 and polarity. In order to better understand SARS-CoV2 physiopathology, this study focuses on the expression pattern of apico-basal polarity proteins during SARS-CoV2 infection.

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