LULISA PROJECT, BIOLUMINESCENCE AS A TOOL FOR HUMAN DIAGNOSTICS, FROM ALLERGY TO COVID19

Key facts

Disease
COVID-19
Funder
Institut Pasteur International Network (IPIN)
Principal Investigator
N/A
Research Location
N/A
Lead Research Institution
N/A
Research Priority Alignment
N/A

Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Immunity
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
Not applicable
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable

Abstract

The LuLISA (Luciferase-Linked ImmunoSorbent Assay) research project aims developing high throughput serological tests for epidemiological studies at local, regional or nation scales. In a recent scientific publication, concerning the detection and dosing of IgE specific to several allergens in patients' blood samples, the use of LuLISA proves to be a vastly improved detection method in comparison with the commercially available kits. The LuLISA has also been adapted to detect various human immunoglobulin types targeting SARS-CoV-2 coronavirus proteins, and it is currently being used as one of the reference methods to evaluate the progress of collective immunity in Covid-19 in France, in collaboration with Santé publique France and several hospitals. This project involves scientists from the Institut Pasteur (Dept. of Immunology and Structural Biology and Chemistry), the CNRS (UMR3523) and the Inserm (U1221, U1222 and UMR1043) in the design of an original assay1 related to an ELISA (Enzyme-Linked ImmunoSorbent Assay). https://www.pasteur.fr/en/research-journal/news/lulisa-project-bioluminescence-tool-human-diagnostics-allergy-covid19

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