LULISA PROJECT, BIOLUMINESCENCE AS A TOOL FOR HUMAN DIAGNOSTICS, FROM ALLERGY TO COVID19

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:235 publications

Grant number: Unknown

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Key facts

  • Disease

    COVID-19
  • Funder

    Institut Pasteur International Network (IPIN)
  • Principal Investigator

    N/A

  • Research Location

    N/A
  • Lead Research Institution

    N/A
  • Research Priority Alignment

    N/A
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The LuLISA (Luciferase-Linked ImmunoSorbent Assay) research project aims developing high throughput serological tests for epidemiological studies at local, regional or nation scales. In a recent scientific publication, concerning the detection and dosing of IgE specific to several allergens in patients' blood samples, the use of LuLISA proves to be a vastly improved detection method in comparison with the commercially available kits. The LuLISA has also been adapted to detect various human immunoglobulin types targeting SARS-CoV-2 coronavirus proteins, and it is currently being used as one of the reference methods to evaluate the progress of collective immunity in Covid-19 in France, in collaboration with Santé publique France and several hospitals. This project involves scientists from the Institut Pasteur (Dept. of Immunology and Structural Biology and Chemistry), the CNRS (UMR3523) and the Inserm (U1221, U1222 and UMR1043) in the design of an original assay1 related to an ELISA (Enzyme-Linked ImmunoSorbent Assay). https://www.pasteur.fr/en/research-journal/news/lulisa-project-bioluminescence-tool-human-diagnostics-allergy-covid19

Publicationslinked via Europe PMC

Creating health systems citizens: enhanced professional identity formation through a para-curricular distinction track in health systems transformation and leadership.

A Comparison of Clinical Diagnostic Classification Criteria Used in Longitudinal Cohort Studies of the Alzheimer's Disease Continuum: A Systematic Review.

Identification and Characterization of a Rare Exon 22 Duplication in <i>CFTR</i> in Two Families.

Structural Rearrangement in Cyclic Cu(II) Pyridyltriazole Complexes: Oxidation of Dabco to Oxalate and CO<sub>2</sub> Conversion to Carbonate.

Administration of FOLFIRINOX for Advanced Pancreatic Cancer: Physician Practice Patterns During Early Use.

Living in a Constant State of Fear: Phenomenological Study on Experiences of Women with High-Risk Pregnancy Waiting for Childbirth in Mpumalanga Province, South Africa.

Self-Administration of Meloxicam via Medicated Molasses Lick Blocks May Improve Welfare of Castrated Calves.

Electrocardiographic Assessment of National-Level Triathletes: Sinus Bradycardia and Other Electrocardiographic Abnormalities.

"Beyond the Finish Line" the Epidemiology of Injury and Illness in Professional Cycling: Insights from a Year-Long Prospective Study.