LULISA PROJECT, BIOLUMINESCENCE AS A TOOL FOR HUMAN DIAGNOSTICS, FROM ALLERGY TO COVID19

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:211 publications

Grant number: Unknown

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Key facts

  • Disease

    COVID-19
  • Funder

    Institut Pasteur International Network (IPIN)
  • Principle Investigator

    Pending
  • Research Location

    N/A
  • Lead Research Institution

    N/A
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    Gender

  • Study Subject

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The LuLISA (Luciferase-Linked ImmunoSorbent Assay) research project aims developing high throughput serological tests for epidemiological studies at local, regional or nation scales. In a recent scientific publication, concerning the detection and dosing of IgE specific to several allergens in patients' blood samples, the use of LuLISA proves to be a vastly improved detection method in comparison with the commercially available kits. The LuLISA has also been adapted to detect various human immunoglobulin types targeting SARS-CoV-2 coronavirus proteins, and it is currently being used as one of the reference methods to evaluate the progress of collective immunity in Covid-19 in France, in collaboration with Santé publique France and several hospitals. This project involves scientists from the Institut Pasteur (Dept. of Immunology and Structural Biology and Chemistry), the CNRS (UMR3523) and the Inserm (U1221, U1222 and UMR1043) in the design of an original assay1 related to an ELISA (Enzyme-Linked ImmunoSorbent Assay). https://www.pasteur.fr/en/research-journal/news/lulisa-project-bioluminescence-tool-human-diagnostics-allergy-covid19

Publicationslinked via Europe PMC

Last Updated:38 minutes ago

View all publications at Europe PMC

Medicine Non-Adherence: A New Viewpoint on Adherence Arising from Research Focused on Sub-Saharan Africa.

Genomic Engineering of Oral Keratinocytes to Establish In Vitro Oral Potentially Malignant Disease Models as a Platform for Treatment Investigation.

Microbial Diversity Impacts Non-Protein Amino Acid Production in Cyanobacterial Bloom Cultures Collected from Lake Winnipeg.

Maternal Diet High in Linoleic Acid Alters Offspring Lipids and Hepatic Regulators of Lipid Metabolism in an Adolescent Rat Model.

Effect of Flour Particle Size on the Glycemic Index of Muffins Made from Whole Sorghum, Whole Corn, Brown Rice, Whole Wheat, or Refined Wheat Flours.

Femtosecond Laser Machining of an X-ray Mask in a 500 Micron-Thick Tungsten Sheet.

The Use of Nautical Activities in Formal Education: A Systematic Review.

Assessing the Psychometric Validity of the Epistaxis Severity Score: Internal Consistency and Test-Retest Reliability.