MECHANISMS OF INTERCELLULAR SPREADING OF SARS-COV-2: ASSESSING THE ROLE OF TNTS TO ESCAPE IMMUNE SURVEILLANCE AND EXPAND TROPISM AND PATHOGENICITY (COVID-Spreads project)
- Funded by Institut Pasteur International Network (IPIN)
- Total publications:0 publications
Grant number: Unknown
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Key facts
Disease
COVID-19Start & end year
N/AFunder
Institut Pasteur International Network (IPIN)Principal Investigator
N/A
Research Location
N/ALead Research Institution
N/AResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
We will study the mechanism of spreading of SARS-CoV-2 between permissive (eg; epithelial) and non-permissive (eg; neuronal) cells, and investigate the role of TNTs, as well as the dependence on the ACE2 receptor. Our cryoEM and FIBSEM set up, will provide unique structural information about this process. Overall, this project will allow understanding the mechanism of the viral neurotropism, as well explain its immune evasion capacity.