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MECHANISMS OF INTERCELLULAR SPREADING OF SARS-COV-2: ASSESSING THE ROLE OF TNTS TO ESCAPE IMMUNE SURVEILLANCE AND EXPAND TROPISM AND PATHOGENICITY (COVID-Spreads project)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:0 publications

Grant number: Unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    Institut Pasteur International Network (IPIN)

  • Research Location

    N/A

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

We will study the mechanism of spreading of SARS-CoV-2 between permissive (eg; epithelial) and non-permissive (eg; neuronal) cells, and investigate the role of TNTs, as well as the dependence on the ACE2 receptor. Our cryoEM and FIBSEM set up, will provide unique structural information about this process. Overall, this project will allow understanding the mechanism of the viral neurotropism, as well explain its immune evasion capacity.