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NEUROLOGICAL IMPLICATIONS OF SARS-COV-2 INFECTION - A TRANSVERSAL STUDY (Neurological project)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:0 publications

Grant number: Unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    Institut Pasteur International Network (IPIN)

  • Research Location

    N/A

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The infection of the nasal mucosa and the lungs by CoV-2 may spread to the CNS, including the brainstem, thereby playing a potential key role in the severe respiratory distress observed in COVID-19. Although several clinical observations support this hypothesis, the knowledge in this field is very limited. To fill this gap, we will investigate CoV-2 neuroinvasion in humans, animal models, and cell culture-based experimental models and decipher the molecular mechanisms involved. Results of this project will provide clues on whether targeting potential neurotropism of CoV-2 may be relevant approach for experimental therapeutics in Covid-19.