RBCG VACCINE SECRETING SARS-COV-2 ANTIGENS (rBCG vaccine project)

Key facts

Disease
COVID-19
Funder
Institut Pasteur International Network (IPIN)
Principal Investigator
N/A
Research Location
N/A
Lead Research Institution
N/A
Research Priority Alignment
N/A

Research Category
Vaccines research, development and implementation
Research Subcategory
Pre-clinical studies
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable

Abstract

Mycobacterium bovis BCG is a live attenuated vaccine that is used since almost 100 years for the vaccination against tuberculosis, with a solid safety record in billions of immunocompetent individuals. The aim of the project is to construct recombinant BCG strains that express viral protein(s) of the SARS-CoV-2 virus in fusion with the 6 kD early secreted antigenic target (ESAT-6), secreted by the type VII secretion systems.

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