Characterization of modulators of the angiotensin-renin system with regard to their effect on an infection with SARS-CoV-2 (CARS)
- Funded by Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)
- Total publications:0 publications
Grant number: 01KI20179
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Key facts
Disease
COVID-19Start & end year
20202020Known Financial Commitments (USD)
$58,500.01Funder
Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)Principal Investigator
Dr. Susanne SchiffmannResearch Location
GermanyLead Research Institution
Fraunhofer-Gesellschaft, MünchenResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
It is currently being discussed whether clinically used active ingredients such as modulators of the angiotensin-renin system could accelerate an infection with SARS-CoV-2. In order to clarify this question, a time-resolved virus infection assay will be established. The assay will help in identifying active substances that promote virus replication, in particular the effect of modulators of the angiotensin renin system on SARS-CoV-2 cell cytotoxicity. In addition, it was postulated that the ACE2 expression downregulated by SARS-CoV-2 is at least partially responsible for the permeability of the lung epithelium induced by SARS-CoV-2 and related lung injury. Therefore it should be tested whether modulators of the angiotensin-renin system affect the permeability of the epithelial tissue. Our findings can fundamentally contribute to the treatment of patients who use modulators of the angiotensin-renin-systems.