Understanding divergent host responses towards SARS-CoV-2 infection through precision immunology (COVIMMUNE)

  • Funded by Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)
  • Total publications:3 publications

Grant number: 01KI20343

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2021
  • Known Financial Commitments (USD)

    $2,778,578.48
  • Funder

    Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)
  • Principle Investigator

    Pending
  • Research Location

    Germany, Europe
  • Lead Research Institution

    Universität Bonn
  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    Gender

  • Study Subject

    Clinical

  • Clinical Trial Details

    Unspecified

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

SARS-CoV-2 infection can trigger a spectrum of host responses ranging from no symptoms to acute respiratory distress syndrome, multi-organ failure and death. Recovered individuals mount an effective immunity, however, some survivors develop COVID-19-associated morbidities, such as lung fibrosis or neurological symptoms. We postulate that the individual immune response during the course of SARS-CoV-2 infection may be an outcome-relevant factor. We have devised a precision immunology approach to systematically study immune functions in SARS-CoV-2-infected individuals that remain asymptomatic or develop COVID-19 with different levels of disease severity. Our central hypothesis is that innate and adaptive immune responses towards SARS-CoV-2 infection are influenced by genetic, epigenetic and environmental factors, which determine the host's ability to mount an efficient and appropriately controlled immune response and that may influence the development of COVID-19-associated pathologies. COVIMMUNE connects clinicians with core expertise in relevant clinical disciplines with experts in virology, immunology, bioinformatics and systems biology. Our approach aims to identify the factors that determine the immune response and clinical outcome of SARS-CoV-2 infection and will reveal predictive signatures to facilitate the development of superior biomarkers for disease susceptibility and personalized treatment.

Publicationslinked via Europe PMC

Last Updated:38 minutes ago

View all publications at Europe PMC

Comparative Analysis of Antibody Titers against the Spike Protein of SARS-CoV-2 Variants in Infected Patient Cohorts and Diverse Vaccination Regimes.

Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination.

Antigen-dependent multistep differentiation of T follicular helper cells and its role in SARS-CoV-2 infection and vaccination.