Genetic risk factors that determine Covid-19 susceptibility and severity

Grant number: Unknown

Grant search

Key facts

  • Disease

    COVID-19
  • start year

    2020
  • Known Financial Commitments (USD)

    $0
  • Funder

    NWO Netherlands
  • Principal Investigator

    Prof dr LH Franke
  • Research Location

    Netherlands
  • Lead Research Institution

    Universitair Medisch Centrum Groningen
  • Research Priority Alignment

    N/A
  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

It is mostly unclear why some people get severely ill due to a Covid-19 infection. We hypothesize this is partly due to genetic risk factors that determine both Covid-19 susceptibility and severity. In this project we will conduct a genome-wide association study in the Lifelines biobank, which has previously generated genotype data for 50,000 participants. We are sending out questionnaires to them, asking about Covid-19 related symptoms, permitting us to study the genetics of Covid-19 infection susceptibility and severity.

Publicationslinked via Europe PMC

Dysregulated Alternative Splicing in Breast Cancer Subtypes of RIF1 and Other Transcripts.

Development and Validation of the Intimate Partner Violence Workplace Disruptions Assessment (IPV-WDA).

Elucidating directed neural dynamics of scene construction across memory and imagination

Implementing a Novel Resident-Led Peer Support Program for Emergency Medicine Resident Physicians.

Cross-Activity Analysis of CRISPR/Cas9 Editing in Gene Families of <i>Solanum lycopersicum</i> Detected by Long-Read Sequencing.

Creating health systems citizens: enhanced professional identity formation through a para-curricular distinction track in health systems transformation and leadership.

A Comparison of Clinical Diagnostic Classification Criteria Used in Longitudinal Cohort Studies of the Alzheimer's Disease Continuum: A Systematic Review.

Identification and Characterization of a Rare Exon 22 Duplication in <i>CFTR</i> in Two Families.

Structural Rearrangement in Cyclic Cu(II) Pyridyltriazole Complexes: Oxidation of Dabco to Oxalate and CO<sub>2</sub> Conversion to Carbonate.