Identification of pan-anti-betacoronaviral compounds using a simple and rapid high-throughput screening approach
- Funded by NWO Netherlands
- Total publications:0 publications
Grant number: Unknown
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Key facts
Disease
COVID-19Start & end year
2020Funder
NWO NetherlandsPrincipal Investigator
Prof dr F ReggioriResearch Location
NetherlandsLead Research Institution
Universitair Medisch Centrum GroningenResearch Priority Alignment
N/A
Research Category
Therapeutics research, development and implementation
Research Subcategory
N/A
Special Interest Tags
N/A
Study Type
Unspecified
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
The goal of this project is to identify lead molecules that specifically target a highly conserved interaction between two coronaviral proteins, which we have recently shown to be vital for coronaviruses. We will establish a miniaturized assay to assess interaction between these two proteins, and use it to screen a library of 100'000 compounds. Hits will be tested in infection models against coronaviruses, including SARS-CoV-2. We expect to identify a therapeutic lead for both the current and future Covid outbreaks