Identification of pan-anti-betacoronaviral compounds using a simple and rapid high-throughput screening approach

The goal of this project is to identify lead molecules that specifically target a highly conserved interaction between two coronaviral proteins, which we have recently shown to be vital for coronaviruses. We will establish a miniaturized assay to assess interaction between these two proteins, and use it to screen a library of 100'000 compounds. Hits will be tested in infection models against coronaviruses, including SARS-CoV-2. We expect to identify a therapeutic lead for both the current and future Covid outbreaks