Understanding infectivity, progression and disease severity of COVID-19 in children [Co-funders: CZI, Rosetree]

Grant number: CV001

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2020
  • Funder

    Wellcome Trust
  • Principle Investigator

    Pending
  • Research Location

    United Kingdom, Europe
  • Lead Research Institution

    Wellcome Sanger Institute
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    Gender

  • Study Subject

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Children (1 year to 12 years)

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

This study will analyse ACE2 and entry associated proteins (such as the viral S protein priming protease TMPRSS2) within the upper airway of children to test the following hypothesise: Hypothesis 1: Reduced expression of ACE2 (cell entry receptor hijacked by the coronavirus) and entry-associated proteins (such as the viral S protein priming protease TMPRSS2) within the upper airway of children compared to adult nasal epithelium is associated with reduced susceptibility and severity of COVID19. Hypothesis 2: Increased expression of immune-associated anti-viral genes in paediatric nasal epithelium compared to adult nasal epithelium accounts for the reduced susceptibility and severity of COVID 19.