Understanding infectivity, progression and disease severity of COVID-19 in children [Co-funders: CZI, Rosetree]
- Funded by Wellcome Trust
- Total publications:0 publications
Grant number: CV001
Grant search
Key facts
Disease
COVID-19Start & end year
20202020Funder
Wellcome TrustPrincipal Investigator
PendingResearch Location
United KingdomLead Research Institution
Wellcome Sanger InstituteResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Subject
Clinical
Clinical Trial Details
Not applicable
Broad Policy Alignment
Pending
Age Group
Children (1 year to 12 years)
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified
Abstract
This study will analyse ACE2 and entry associated proteins (such as the viral S protein priming protease TMPRSS2) within the upper airway of children to test the following hypothesise: Hypothesis 1: Reduced expression of ACE2 (cell entry receptor hijacked by the coronavirus) and entry-associated proteins (such as the viral S protein priming protease TMPRSS2) within the upper airway of children compared to adult nasal epithelium is associated with reduced susceptibility and severity of COVID19. Hypothesis 2: Increased expression of immune-associated anti-viral genes in paediatric nasal epithelium compared to adult nasal epithelium accounts for the reduced susceptibility and severity of COVID 19.