Single cell molecular signatures in blood and tissues from mild and severe COVID19 patients

Grant number: CV002

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2020
  • Funder

    Wellcome Trust
  • Principle Investigator

    Pending
  • Research Location

    United Kingdom, Europe
  • Lead Research Institution

    Wellcome Sanger Institute
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    Gender

  • Study Subject

    Non-Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Key questions: What immune pathways and cellular phenotypic states distinguish COVID-19 severity? How do immune cell populations in blood and lung relate in severe COVID-19? Aims: To uncover immune signatures underlying severe disease, revealing candidate immune pathways involved in pathogenesis, Identify candidate predictive biomarkers for larger scale studies, Rapidly provide robust in vivo evidence to guide therapeutic intervention