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Immune and Omics Cell Atlas of COVID-19 patients with pre-existing autoimmunity and immunodeficiency

Grant number: CV005

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2020
    2020

  • Known Financial Commitments (USD)

    $0

  • Funder

    Chan Zuckerberg Initiative

  • Principal Investigator

    Roser Vento

  • Research Location

    United Kingdom, Spain

  • Lead Research Institution

    Wellcome Sanger Institute

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen genomics, mutations and adaptations

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Adults (18 and older)

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

This work aims to provide knowledge about the immunological, transcriptome and epigenome state of SARS-CoV-2 infection in patients with pre-existing immunological disorders. We will characterize the overall local (nasal swab) and systemic (peripheral blood) immune response to SARS-CoV-2 infection in a spectrum of patients with primary immunodeficiency and autoimmune disease. Knowledge generated from this study will be key to understand the underlying immunopathogenesis and host susceptibility to SARS-CoV-2 infection.