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Susceptibility of human fetal cells to SARS-CoV2 and viral infection

Grant number: CV015

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2020
    2021

  • Funder

    Wellcome Trust

  • Principal Investigator

    Muzlifah Haniffa, Sarah Teichmann

  • Research Location

    United Kingdom

  • Lead Research Institution

    Wellcome Sanger Institute

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

In this study, we will assess the susceptibility of fetal cells and tissues, that are likely to encounter virus following vertical transmission, to SARS-CoV2 infection. Key questions: • Can fetal cells sense and respond to SARS-CoV2? • Can fetal cells become infected to SARS-CoV2? • What are the immunological and molecular consequences of sensing of and infection by SARSCoV2 to fetal cells and their tissue microenvironment?