Monitoring the evolution, spread and transmission of SARS-CoV-2 through whole genome sequencing to enable fast genotype to phenotype prediction

  • Funded by Netherlands Organisation for Health Research and Development (ZonMW)
  • Total publications:0 publications

Grant number: 1.01501E+13

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2021
  • Known Financial Commitments (USD)

    $483,823.6
  • Funder

    Netherlands Organisation for Health Research and Development (ZonMW)
  • Principle Investigator

    Pending
  • Research Location

    Netherlands, Europe
  • Lead Research Institution

    Erasmus Medical Centre
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen genomics, mutations and adaptations

  • Special Interest Tags

    Gender

  • Study Subject

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Emerging viral infections, once established in the human population, may evolve with continued circulation. The evolution of SARS-CoV-2 in the Netherlands will be monitored throughout the phases of the pandemic with close to real-time whole genome sequencing, allowing fast responses in case of remarkable genomic changes, and providing a reference database for investigation of community outbreaks. Bioinformatic tools will be developed to rapidly identify changes that may impact ability to detect, treat and prevent infections. In case novel lineages start to emerge, the effects on transmission dynamics will be further investigated using in vitro and in vivo studies to specifically look at the receptor binding properties, pathogenicity and other relevant virus properties. The results will directly inform precise public health decision making to control the outbreak.