Understanding the molecular basis and the role of risk factors in Coronavirus infection (SARS-CoV-2 or COVID-19) in preclinical models
- Funded by Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)
- Total publications:3 publications
Grant number: 2020/04746-0
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Key facts
Disease
COVID-19Start & end year
20202022Known Financial Commitments (USD)
$32,119.5Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)Principal Investigator
Daniel Martins-de-SouzaResearch Location
BrazilLead Research Institution
Universidade Estadual de CampinasResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified
Abstract
Rapidly, SARS-CoV-2 viral infections took on pandemic dimensions, leading several countries to a state of public calamity. Using a methodology not directed by hypothesis, based on proteomic and metabolomic analyzes, the present project aims to identify the molecular mechanisms involved in SARS-CoV-2 infection in macrophage cultures, pulmonary epithelium as well as neurons and astrocytes. We will also investigate tissues from preclinical models such as brain, lung and bronchoalveolar lavage. We intend to provide clarifications about SARS-CoV-2 infection, proposing new therapeutic targets that can bring better perspectives regarding the spread of the disease and, consequently, provide an improvement in the quality of life of infected individuals.