Caracterização de fatores de risco intrínsecos e o desenvolvimento de novas alternativas de diagnóstico e tratamento para COVID-19 [Google Translate : Characterization of intrinsic risk factors and the development of new diagnostic and treatment alternatives for COVID-19]

  • Funded by Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)
  • Total publications:4 publications

Grant number: 2020/04558-0

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2022
  • Known Financial Commitments (USD)

    $34,960
  • Funder

    Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)
  • Principle Investigator

    Pending
  • Research Location

    Brazil, Americas
  • Lead Research Institution

    Universidade Estadual de Campinas
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Diagnostics

  • Special Interest Tags

    Gender

  • Study Subject

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The arrival of SARS-CoV-2 in Brazil in March 2020 had a negative impact on the economy, generated panic in the population and disrupted our country's public and private health systems. It is evident the need for methods of rapid diagnosis / prognosis and alternative therapies that help to face this pandemic in our country. Thus, this multidisciplinary project, which involves researchers from several units at Unicamp and other research institutions in Brazil and abroad, aims to use clinical specimens (nasopharyngeal swab, serum and frozen whole blood) already used in the diagnosis and other routine examinations and stored at the Clinical Pathology Laboratory of HC to: (1) Assess the circulation and genetic diversity of Covid-19 in Campinas; (2) Search for biomarkers that help us in the rapid diagnosis or in the prediction of fatal cases, using methodologies of proteomics, metabolomics and multiplex immunoassays; (3) Identify new antivirals through the repositioning of drugs already approved for use in humans, in addition to the discovery of new drug candidates, by computer screening tests and antiviral activity test in cell culture in a level 3 biological containment laboratory.

Publicationslinked via Europe PMC

Last Updated:37 minutes ago

View all publications at Europe PMC

Diving into the proteomic atlas of SARS-CoV-2 infected cells.

Heterogeneity of humoral response patterns in mildly symptomatic, non-hospitalized COVID-19 patients: A one-year longitudinal study.

Increased mTOR Signaling and Impaired Autophagic Flux Are Hallmarks of SARS-CoV-2 Infection.

Rapid clinical recovery of a SARS-CoV-2 infected common variable immunodeficiency patient following the infusion of COVID-19 convalescent plasma.