Determining molecular candidates that contribute to the high risk of COVID-19 in elderly individuals

  • Funded by Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)
  • Total publications:2 publications

Grant number: 2020/04919-2

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2022
  • Known Financial Commitments (USD)

    $30,598.05
  • Funder

    Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)
  • Principle Investigator

    Pending
  • Research Location

    Brazil, Americas
  • Lead Research Institution

    Universidade Estadual de Campinas
  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    Gender

  • Study Subject

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

COVID-19 has recently emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-driven and unsupervised data-based approaches, as well as patients and preclinical models, we hope to find proteins and candidate pathways that can not only predict disease susceptibility, but also unravel the molecular mechanisms through which aging contributes to SARS-Cov-2 infection. We also hope to propose drugs approved by the FDA and ANVISA that can potentially target these pathways to prevent, mitigate or eliminate viral infection. Our general objective is to elucidate how aging constitutes the main risk factor for COVID-19, providing possible solutions for its pandemic.

Publicationslinked via Europe PMC

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