Determining molecular candidates that contribute to the high risk of COVID-19 in elderly individuals
- Funded by Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)
- Total publications:2 publications
Grant number: 2020/04919-2
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Key facts
Disease
COVID-19Start & end year
20202022Known Financial Commitments (USD)
$30,598.05Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)Principal Investigator
Marcelo Alves da Silva MoriResearch Location
BrazilLead Research Institution
Universidade Estadual de CampinasResearch Priority Alignment
N/A
Research Category
Clinical characterisation and management
Research Subcategory
Prognostic factors for disease severity
Special Interest Tags
N/A
Study Type
Clinical
Clinical Trial Details
Not applicable
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified
Abstract
COVID-19 has recently emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-driven and unsupervised data-based approaches, as well as patients and preclinical models, we hope to find proteins and candidate pathways that can not only predict disease susceptibility, but also unravel the molecular mechanisms through which aging contributes to SARS-Cov-2 infection. We also hope to propose drugs approved by the FDA and ANVISA that can potentially target these pathways to prevent, mitigate or eliminate viral infection. Our general objective is to elucidate how aging constitutes the main risk factor for COVID-19, providing possible solutions for its pandemic.
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