Modeling of COVID-19 in vitro and in silico

  • Funded by Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)
  • Total publications:1 publications

Grant number: 2020/05289-2

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2022
  • Known Financial Commitments (USD)

    $70,226.37
  • Funder

    Fundação de Amparo à Pesquisa do Estado de São Paulo [São Paulo Research Foundation] (FAPESP)
  • Principle Investigator

    Pending
  • Research Location

    Brazil, Americas
  • Lead Research Institution

    Universidade Federal de São Paulo
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Disease models

  • Special Interest Tags

    Gender

  • Study Subject

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The new coronavirus SARS-CoV-2 emerged in December 2019 in China and spread to several countries, causing an acute respiratory disease called COVID-19 (Coronavirus disease 2019). COVID-19 can evolve into severe respiratory infections resulting in a high death rate for individuals over 60 and also patients with chronic diseases, such as diabetes and cardiovascular diseases. COVID-19 was declared a pandemic by the World Health Organization (WHO) in March 2020. At a time when the COVID-19 pandemic is expanding globally, we saw the opportunity to contribute our expertise in two distinct but closely related strands with research projects developed by our group: 1) development of a platform to model SARS-CoV-2 infection in vitro using 3D bioprinting; and 2) production of an in silico model for studies of the spread of contagion by SARS-CoV-2 in Brazil. We propose a multidimensional study that aims to provide tools that can be used for in vitro studies of infection and drug tests, and an in silico model for assessing and predicting the impact of COVID-19. Once validated, the in vitro models will be available for use by researchers who are interested in studying mechanisms of pulmonary and cerebral infection, new treatments to combat infection by SARS-CoV-2, among other possibilities. The in silico modeling of the COVID-19 pandemic may be an important tool for the establishment of public policies to face the pandemic, both in aspects of collective health and in the mitigation of social and economic impacts.

Publicationslinked via Europe PMC

Last Updated:37 minutes ago

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Protocol for designing and bioprinting multi-layered constructs to reconstruct an endothelial-epithelial 3D model.