Genomic Resource Grant for the PhenX Toolkit - expansion and sustainabilityPhenX Supplement for COVID-19 Research

PROJECT SUMMARY/ABSTRACTBiomedical science in the 21st century is a multidisciplinary and data-intensive enterprise that relies on clearspecification of research methods and results. The reproducibility of findings and the meta-analysis of pooleddata from disparate sources are both catalyzed by standard approaches to acquiring and representing data.In this context, the PhenX (consensus measures for Phenotypes and eXposures) Toolkit(https://www.phenxtoolkit.org/) is an increasingly valuable catalog of standard measures and bioinformaticstools that help investigators improve the quality and consistency of data collection and identify opportunitiesfor collaborative research. Measures in the PhenX Toolkit are selected by working groups (WGs) of domainexperts using a consensus process and criteria established by the PhenX Steering Committee (SC). Sinceits launch, PhenX has expanded beyond standard measures for genome-wide association studies (GWAS)of common, complex diseases to include domains such as Rare Genetic Conditions, Sickle Cell Disease,and Tobacco Regulatory Research.The specific aims of the proposed Administrative Supplement "PhenX Measures for COVID-19" are asfollows: Specific Aim 1: Develop COVID-19 Core and Specialty collections. Specific Aim 2: Develop featuresand tools for the COVID-19 page. Specific Aim 3: Establish PhenX measurement protocols for COVID-19outcomes.The crowd-sourcing approach defined here will rapidly establish COVID-19 Core and Specialty Collectionsand raise awareness of the COVID-19 measurement protocols available in the PhenX Toolkit.Body Text (nomore than 30 lines)