Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study

Project Summary: The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) isthe first and only nationally representative and publicly available dataset on late-life cognition and dementia inIndia. It administers the Harmonized Cognitive Assessment Protocol (HCAP) that is designed to beharmonized with ongoing longitudinal studies of aging around the world, including the Health and RetirementStudy (HRS) in the United States, and prior studies in India. This rich set of cognitive phenotypes and a varietyof other health and social environment phenotypes, as well as genotype data from whole genome sequencing,give us a unique opportunity to identify the mutational spectrum underlying risk of dementia and AD in arepresentative sample of India. In this application, we aim to monitor and investigate the impacts of Coronavirus Disease 2019 (COVID-19)on the LASI-DAD households through phone surveys. The COVID-19 pandemic will fundamentally alter thelives of individuals across the world, and India is not an exception. To gain insight into the health and economicimpacts of the pandemic, we propose to track the LASI-DAD households and conduct quarterly phoneinterviews for 1-year. Through continuous monitoring, we will assess how individuals' knowledge, attitudes,and behaviors related to the disease change over time, as well as the health and economic impacts of thepandemic. The collected data will be linked to the follow-up Wave 2 LASI-DAD for the estimation of theirimpacts on cognitive changes and dementia incidence.