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A Precision high content screening assay for AB-mediated neuronal cell cycle reentry

  • Funded by National Institutes of Health (NIH)
  • Total publications:0 publications

Grant number: 3R01AG063400-02S1

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2019
    2022

  • Known Financial Commitments (USD)

    $161,500

  • Funder

    National Institutes of Health (NIH)

  • Principal Investigator

    Elizabeth Sharlow

  • Research Location

    United States of America

  • Lead Research Institution

    University Of Virginia

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Project Summary: We have established a human iPS-derived neuronal-glial cell model system that we areusing to (1) study AβO-induced neuronal cell cycle reentry (CCR) as well as (2) screenfor compounds that inhibit AβO-induced neuronal CCR. We now propose to adapt thiscell-based model system to evaluate the effects on SARS-CoV-2 spike protein-ACE2binding on neuronal "fitness", responsiveness and intracellular signaling as well as use toscreen for small molecule inhibitors that may used for the next generation SARS-CoV-2therapeutics.