CRISOL: Building Community Resilience and Integrating Efforts to Understand and Address Syndemic Health Conditions Afflicting Young LatinoImmigrants

This goal of this competitive revision is to expand our original project to adapt, implement and evaluate a multi-level intervention to mitigate the multi-dimensional toll of COVID19 among Latino immigrant communities inPhiladelphia. Evidence of effective strategies to curb the pandemic, reduce disparities and mitigate its impactis lacking and very urgent. In the US, Latino immigrants are one of the groups hardest hit by this pandemic,with recent steep increases in COVID-19 deaths among this group corroborating their continued increased riskof infection and increased susceptibility. Latino immigrants have long exhibited disparities in diabetes, obesityand hypertension, factors known to increase COVID-19 related severity, and also in Substance Abuse,Violence exposure, HIV/AIDS, and MEntal health (SAVAME) syndemic. These syndemic conditions have beenworsened in the context of COVID-19. Latino immigrants represent a hard-to-reach and marginalizedpopulation, with extremely limited access to adequate health care and safety nets. This group faces manystructural barriers, and social vulnerabilities, that hinder their capacity to access COVID-19 testing andtreatment services and to adhere to public health interventions and measures to decrease the spread ofCOVID-19. Latinos often rely on a thin and fragmented network of health and social services organizations.Intervention to mitigate the impact of COVID-19 on this population will need to have a broad stakeholderengagement and address a wide range of health determinants. Peer-driven interventions have been effectivefor the prevention and control of infectious diseases such as HIV, STIs among Latino populations.Strengthening the links between community members and these organizations and promoting inter-organizational coordination to meet syndemic health, behavioral, economic, and legal needs of Latinocommunities are essential elements to mitigate the impact of COVID-19 on this low-resource population. Indirect response to the NOT-MD-20-022/PAR PA-18-935, our ongoing community-academic partnershipproposes to evaluate "CRISOL Contigo," a multi-level intervention to address the needs created or magnifiedby the COVID-19 pandemic among Latino communities in Philadelphia. CRISOL Contigo includes a peer-driven program and mobilization of Latino-serving organizations. In aim 1, we will adapt an ongoing PopularOpinion Leader (POL) program to address the unique health, social, and economic needs related to COVID-19and the SAVAME syndemic. In aim 2, we will assess the efficacy of CRISOL Contigo to improve COVID-19related preventive health behaviors and use and access to COVID-19 related testing and care (co-primaryoutcomes). In aim 3, we will examine the impact of CRISOL Contigo on community assets, interagencycollaborations and coordination among the Latino-serving organizations in Philadelphia. There are almost 20million Latino immigrants in the US, and they play a central role in sustaining the vital parts of the US economyTailored, multi-level interventions that consider the unique needs of Latinos are urgently needed to mitigate theimpact of this and future outbreaks of COVID-19 on this disadvantaged population.