Cytoscape: A Modeling Platform for Biomolecular Networks

This application is being submitted in response to NOT-HG-20-030. We will use data-driven network andhierarchical modeling techniques enabled by Cytoscape ecosystem tools and resources to build models ofSARS-CoV-2 infection and will use the models to propose mechanisms of variance in host response based onthe analysis of population genetic and COVID-19 disease outcome data. These data-driven models will informresearch in population risk stratification and potential COVID-19 therapies. Our models, analysis results, andtoolset will be made available to the research community via a website and data repository. The models will bederived from molecular and genetic interaction data and will be used to analyze population data onSARS-CoV-2 infection, comorbidities, and clinical outcomes currently being collected by the UK BioBank. Theanalysis will be updated periodically with each release of data, maintaining an up-to-date resource for theresearch community. The modeling tools and pipelines will be user-friendly and well-documented, enablingresearchers to build alternative models or to analyze other population data.