University of California Health Participation in the National COVID Cohort Collaborative (N3C)

PROJECT Summary: Through this supplement, we will orchestrate a collective effort across the five CTSA Hubs at the University ofCalifornia (UC) Health to contribute data to, and become a strategic partner of, the National COVID Cohort Collaborative (N3C). By combining the data resources and research informatics expertise at UC Davis, San Francisco, Los Angeles, Irvine, and San Diego, UC Health is uniquely positioned to provide high-quality clinical data of diverse patient populations across the State of California to help N3C fulfill its mission to "build a centralized national data resource that the research community can use to study COVID-19 and identify potential treatments as the pandemic continues to evolve." The proposed work will leverage an existing UC-wide initiative on curating the UC COVID Research Data Set (UC CORDS), a continuously updated HIPAA Limited Data Set that contains comprehensive clinical information of all patients tested for COVID-19 at any UC Health facility. To ensure high-quality and timely data delivery, we will create a UC-wide governance structure to establish a master Data Transfer and Use Agreement (DTUA) with NCATS on behalf of all five UCCTSA Hubs, in addition to coordinating research ethics reviews. We will also create an informatics task force involving key stakeholders at each UC CTSA Hub to coordinate site-level data work. Data aggregation, quality assurance, and submission will be performed by the UC Health Data Warehouse (UCHDW) team at the Centerfor Data-Driven Insights and Innovation (CDI2) in the UC Office of the President.Glossary ACT Accrual to Clinical TrialsCDI2 Data-Driven Insights and Innovation CDW Clinical Data WarehouseCMBI Center for Biomedical InformaticsCOVID-19 Coronavirus Disease 2019 (COVID-19)CTSA Clinical and Translational Science AwardsDTUA Data Transfer and Use AgreementEHR Electronic health recordsi2b2 Informatics for Integrating Biology and the BedsideN3C National COVID Cohort CollaborativeOMOP Observational Medical Outcomes PartnershipPCORnet National Patient-Centered Clinical ResearchNetworkSHRINE Shared Health Research Information NetworkUC BRAID University of California Biomedical ResearchAcceleration, Integration, and DevelopmentUC CORDS University of California COVID ResearchData SetUC Davis CTSC University of California, Davis Clinicaland Translational Science CenterUC Irvine ICTS University of California, Irvine Institute forClinical and Translational ScienceUC ReX University of California Research ExchangeUCHDW University of California Health Data WarehouseUCLA CTSI University of California, Los Angeles Clinicaland Translational Science InstituteUCSD ACTRI University of California, San Diego AltmanClinical and Translational Research InstituteUCSF CTSI University of California, San FranciscoClinical and Translational Science Institute