Identification of host RNA binding proteins that are recruited/required by SARS-CoV-2 during its infection cycle to elucidate therapeutic targets_x005F_x005F_x005F_x005F_x005F_x005F_x005F_x000D_ _x005F_x005F_x005F_x005F_x005F_x005F_x005F_x000D_

If immune cells (lymphocytes) are infected by this (SARS-CoV-2), then assumptions that patients previously infected are now immune may be incorrect. The project will devise new methods to detect and visualize SARS-CoV-2 directly in infected human tissues to determine which immune cells could be infected, which sub-class of two types of immune cells (T and B cells) are affected and which immune cells of the digestive tract may be affected. These methods will be able to confirm viral infection in deceased cases where a diagnosis was not made. _x005F_x005F_x005F_x005F_x005F_x005F_x005F_x000D_ _x005F_x005F_x005F_x005F_x005F_x005F_x005F_x000D_ Identification of host RNA binding proteins that are recruited/required by SARS-CoV-2 during its infection cycle to elucidate therapies that target viral replication. The protein synthesis machinery suggested by data to be used by the virus, is currently being explored as an anti-cancer target by all major pharmaceutical companies and there are many drugs that can be used in this regard which have been through clinical trial and are readily available._x005F_x005F_x005F_x005F_x005F_x005F_x005F_x000D_ _x005F_x005F_x005F_x005F_x005F_x005F_x005F_x000D_