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CoV-2RBP Identification of proteins interacting with SARS-CoV-2 RNA during viral replication

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Known Financial Commitments (USD)

    $0

  • Funder

    ANR

  • Principal Investigator

    Sarah Gallois- Montbrun

  • Research Location

    France

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The CoV-2RBP project aims to identify viral and cellular factors that interact with SARS-CoV-2 RNAs and impact viral replication in cellular models of infection. They will mobilize cellular and molecular approaches to specifically label SARS-CoV-2 RNA, then isolate viral RNA-protein complexes, and identify interaction factors by mass spectrometry. The proteins of interest will then be validated for their interaction with SARS-CoV-2 RNA and their role in viral replication will be studied.