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Neutrosets Roles of Neutrophil subpopulations in severe COVID-19 and its thrombotic complications

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Known Financial Commitments (USD)

    $0

  • Funder

    ANR

  • Principal Investigator

    Christophe Combadière

  • Research Location

    France

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The Neutrosets project aims to determine whether a neutrophil profile specifically induced by SARS-CoV-2 infection could be a good indicator of the health status of COVID patients. For this, he proposes to better characterize the subpopulations of neutrophils in COVID-19 patients and to see how neutrophil dysregulation, triggered by inappropriate functional differentiation, causes a critical clinical state with thromboembolic complications, by combining an analysis ex vivo in patients and a preclinical mouse model of COVID-19.