Return to homepagePandemic Pact

SEx-bias-CoV2 Gender bias in COVID-19 disease: Impact of X-linked mechanisms on innate and adaptive anti-SARS-CoV2 immunity

Grant number: unknown

Grant search

Key facts

  • Disease

    COVID-19

  • start year

    -99

  • Known Financial Commitments (USD)

    $0

  • Funder

    ANR

  • Principal Investigator

    Jean-Charles Guéry

  • Research Location

    France

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The SEx-bias-CoV2 project focuses on the assessment of gender bias in COVID-19 disease, including the impact of X-linked mechanisms on innate and adaptive anti-SARS-CoV-2 immunity. Hypothesizing that gene-dosing effects due to X chromosome (ICX) inactivation could potentially contribute to sex-related differences in COVID-19, the team will test the role of ICX escape of the Tlr7 gene in the production of type I IFN and in the vaccine response to SARS-CoV2 in mice. The project will also assess whether there is a gender bias in the functional response of human plasmacytoid dendritic cells (pDCs) in response to SARS-CoV-2.