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SUD-COVID-G4 Interaction between the SUD domain of SARS-CoV-2 and guanine quadruplexes (G4), screening for G4 ligands with antiviral properties

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    ANR

  • Principal Investigator

    Unspecified Marc Lavigne

  • Research Location

    France

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The SUD-COVID-G4 project proposes to identify antiviral molecules targeting the interaction between the Nsp3 protein of SARS-CoV-2, which plays an essential role in the replication of the virus, and guanine quadruplexes (G4) formed in cellular RNAs from infected cells. It will specifically target the interaction between the SUD domain of SARS-CoV-2 and cellular G4s.