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COVAFFIT Identification of Affitins neutralizing SARS-Cov-2

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    ANR

  • Principal Investigator

    Unspecified Frédéric Pecorari

  • Research Location

    France

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The COVAFFIT project aims to generate small artificial affinity proteins (Affitins) in vitro, using the RBD domain, the S protein and pseudo-typed particles as targets, then to screen and identify Affitins capable of neutralizing the infection. by SARS-Cov-2. The best Affitin candidates will then be characterized in vitro for their affinity, their specificity and their ability to prevent entry of the virus into cells.