AABIFNCOV Genetic and immunological basis of autoantibodies against type I interferons predisposing to severe forms of COVID-19.

The AABIFNCOV project concerns the study of the genetic and immunological bases of autoantibodies (auto-Ab) directed against type I interferons and predisposing to severe forms of Covid-19. He will focus on detecting the presence of these auto-antibodies with more sensitive methods, in large cohorts of patients with different grades of severity, but also in family members of individuals with auto-Ac, in the plasma of convalescent patients intended for transfusion, in subjects with only one functional X chromosome, as well as in individuals of the general population. It will also analyze by sequencing the whole genome the genetic variants, in particular linked to the X chromosome, which could explain the development of these auto-Acs, and validate them experimentally.