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DARK-COVID inhibition of SARS-CoV2 replication by unreferenced and non-coding genes in human cells

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • start year

    -99

  • Known Financial Commitments (USD)

    $0

  • Funder

    ANR

  • Principal Investigator

    Antonin Morillon

  • Research Location

    France

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The DARK-COVID project aims to identify and characterize non-coding and unreferenced genes that exhibit as yet uncharacterized inhibitory activities against SARS-CoV-2. He will combine total transcriptome approaches with genetic engineering on infected human cells, with the aim of identifying unreferenced RNAs and long non-coding RNAs (lncRNAs) that play a role in virus replication. A first molecular analysis will be carried out to provide preliminary information on their mechanisms of action.