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CORONET Role of NET / DNase balance in the severity of COVID-19

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • start year

    -99

  • Known Financial Commitments (USD)

    $0

  • Funder

    ANR

  • Principal Investigator

    Chloé James

  • Research Location

    France

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Epidemiological studies

  • Research Subcategory

    Disease susceptibility

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The CORONET project aims to determine whether increased neutrophil extracellular traps (NET) biomarkers predict oxygen requirement in symptomatic outpatients newly diagnosed with Covid-19, to determine whether the decrease in DNase activity correlates with increase in NET biomarkers and respiratory failure, and finally to study the mechanisms responsible for the decrease in DNase activity. This project may pave the way for new therapeutic perspectives to reduce NETs, ​​in particular the administration of exogenous DNase.