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RIPCOV Roles of type I interferons and plasmacytoid dendritic cells in Covid19

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Known Financial Commitments (USD)

    $0

  • Funder

    ANR

  • Principal Investigator

    Marc Dalod

  • Research Location

    France

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The RIPCOV project is studying the roles of type I interferons (IFN-I) and plasmacytoid dendritic cells (pDCs) in Covid-19. He will use mouse models to trace or inactivate pDCs in vivo and follow IFN-I producing cells with a high degree of resolution. This approach will test the hypothesis that IFN-I and pDCs could play either a beneficial or a deleterious role, depending on their activation dynamics from the first days after infection, which is itself dose-dependent. infectious virus received or the initial effectiveness of viral control.