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SirocCo Global and single cell sequencing of the TCR repertoire in COVID-19

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    ANR

  • Principal Investigator

    Unspecified Encarnita Mariotti

  • Research Location

    France

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The SirocCo project suggests that the specificity of the T lymphocyte (LT) response is a major determinant of the outcome of Covid-19, and proposes to precisely analyze the composition of the LT receptor repertoire (TCR) of the main LT populations in the blood and at the site of inflammation. It is expected to provide TCR signatures from Treg and Teffs that will describe the specificity of the LT response in Covid-19 with a view to better understanding the pathophysiology of the disease, discovering biomarkers of severity, and designing treatments and vaccines.