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Understanding the role of SARS-CoV-2 virulence factorOrf3a in modulating host cell responses: a way to identify host-directed therapy

Grant number: CVD/2020/000733

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    SERB India

  • Principal Investigator

    Dr. Amit Tuli

  • Research Location

    India

  • Lead Research Institution

    CSIR-Institute of Microbial Technology

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Drug repurposing against key COVID-19 targets

1 Publication linked via Europe PMC

Last Updated:4 days ago

View all publications at Europe PMC

SARS-CoV-2 virulence factor ORF3a blocks lysosome function by modulating TBC1D5-dependent Rab7 GTPase cycle.