Development and Evaluation of diagnostics and Candidate VACacines for emerging SARS-Coronavirus-2 (DEC-VAC SARS)

Grant number: IPA/2020/000070

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Key facts

  • Disease

    COVID-19
  • Funder

    SERB India
  • Principal Investigator

    Dr. StalinRaj Victor
  • Research Location

    India
  • Lead Research Institution

    Indian Institute of Science Education and Research, Thiruvananthapuram
  • Research Priority Alignment

    N/A
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Diagnostics

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Investigational vaccines against respiratory viruses

Publicationslinked via Europe PMC

Lumazine Synthase Nanoparticles as a Versatile Platform for Multivalent Antigen Presentation and Cross-Protective Coronavirus Vaccines.

Quantitative Proteomic Analysis Reveals JMJD6 and DNAJB11 as Endogenous Substrates of E3 Ligase RFFL.

Endosomal RFFL ubiquitin ligase regulates mitochondrial morphology by targeting mitofusin 2.

CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono-ubiquitination.

SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial Cells.

Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria.

The use of Pseudotyped Coronaviruses for the Screening of Entry Inhibitors: Green Tea Extract Inhibits the Entry of SARS-CoV-1, MERSCoV, and SARS-CoV-2 by Blocking Receptor-spike Interaction.

SARS-CoV-2 Cellular Entry Is Independent of the ACE2 Cytoplasmic Domain Signaling.