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CORONA - ViKon - Targeted elimination of SARS-CoV-2 by microparticle-based high-affinity Visrus binding conjugates; subproject 2: Polymer-based nanoparticles and microparticles with antiviral binding motifs.

  • Funded by Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)
  • Total publications:0 publications

Grant number: 03COV17B

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2021
    2023

  • Known Financial Commitments (USD)

    $449,318.2

  • Funder

    Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)

  • Principal Investigator

    Ulrich S Schubert

  • Research Location

    Germany

  • Lead Research Institution

    Friedrich-Schiller-Universität Jena

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

In this subproject, the chemical and polymer chemical work as well as the formulation of the polymers for the production of the virus-binding particles will be carried out. The aim is to prepare polymers with reactive end groups to which short ACE2 receptor peptides (produced in AS1) are coupled. By varying the coupling chemistry and the conditions for formulating the polymer-peptide conjugates into nanoparticles and microparticles, optimized particles for binding SARS-CoV-2 viruses will be obtained. The subproject is thus integrated into the main focus 2 (AS2) of the joint project. However, in close collaboration with the cooperation partners, supporting work will also be carried out in AS3 and AS5.