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RNA Granule Bursting: A new paradigm for combating SARS-CoV-2 "(additional Corona-related funding)

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • start year

    2020

  • Funder

    Volkswagen Stiftung

  • Principal Investigator

    Dr. Kashif Sadiq

  • Research Location

    Germany

  • Lead Research Institution

    HITS Heidelberger Institut für Theoretische Studien

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The question addressed by this project is whether SARS-CoV-2 regulates its intracellular RNA replication by forming RNA granules in which to shelter its RNA. By developing a computational pipeline to screen host cell RNA-binding proteins (RBPs) against the viral RNA and a mathematical model of viral RNA processing, the research group will determine, which RBPs most critically affect granule-regulated virus replication. This will create a new antiviral therapy paradigm for SARS-CoV-2 that modulates host cell RBPs rather than directly inhibiting viral enzymes.