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RNA Degradation via OAS-RNase L Activation as a Novel Anti-Coronavirus Strategy

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2020

  • Funder

    Volkswagen Stiftung

  • Principal Investigator

    Dr. Peng Wu

  • Research Location

    Germany

  • Lead Research Institution

    Max-Planck-Institut für molekulare Physiologie

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Anti-coronavirus therapeutics with new mechanisms of function are urgently needed to address the current SARS-Cov-2 pandemic and prepare for future coronavirus diseases. Within this project, first-in-class small molecules activating the OAS-RNase L pathway are to be identified to degrade viral RNA and accelerate viral clearance. The mechanism of RNA degradation via small-molecule OAS activators will be evaluated for the first time to develop therapeutic candidates.