Developing Methods for Comparing Outcomes Across Patient Groups in Observational Studies

This enhancement seeks to develop and apply subgroup analysis methods developed in the primary project to overcome limitations and biases in clinical trial and observational data in their representation of subgroups and the at-large target population. These methods use small trial and observational study findings about different medication treatment effects on COVID-19 outcomes and apply these findings to target populations and important subgroups. The enhancement will Establish criteria and develop a tool to facilitate rigorous assessment of observational treatment comparisons in the setting of COVID-19 Illustrate application of those criteria and tools to critically evaluate and interpret comparative effectiveness analyses of three COVID-19-related therapies using claims data on safety and efficacy outcomes