Identifying SARS-CoV-2 Vulnerabilities
- Funded by University of Minnesota
- Total publications:0 publications
Grant number: unknown
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Key facts
Disease
COVID-19start year
-99Known Financial Commitments (USD)
$0Funder
University of MinnesotaPrincipal Investigator
PhD. Alon HerschhornResearch Location
United States of AmericaLead Research Institution
Medical School, University of MinnesotaResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Type
Unspecified
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
Entry of SARS-CoV-2 into target cells is mediated by the interactions of the viral envelope glycoproteins (Envs) and the receptor(s) on the surface of host cells. The SARS-CoV-2 Envs are the sole target of neutralizing antibodies and the potential focus for vaccine development and therapeutic interventions. Led by Alon Herschhorn, PhD, assistant professor of medicine, this study aims to optimize a system for studying SARS-Cov-2 entry and to identify Env amino acids that are critical for virus entry. "Understanding SARS-CoV-2 Env function and identifying critical residues to mediate entry will build a basis for developing new vaccines and for therapeutic targeting of viral replication," said Herschhorn. "This study will also inform us about the ability of the virus to escape interventions and become resistant."