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Structural Basis of Remdesivir Inhibiting SARS-2 Transcription

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    University of Minnesota

  • Principal Investigator

    PhD. Bin Liu

  • Research Location

    United States of America

  • Lead Research Institution

    The Hormel Institute, University of Minnesota

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    Prophylactic use of treatments

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Led by Bin Liu, PhD, assistant professor, the Hormel Institute, this study will provide a structural basis for understanding the mechanisms of how COVID-19 virus transcription is inhibited by Remdesivir, and therefore pave the way for discovering more effective antiviral drugs. "The information gained from our proposed study will greatly advance the understanding of COVID-19 virus replication/transcription machinery, and facilitate the development of novel antiviral drugs and novel therapeutic strategies for SARS-2 infection," said Liu.