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Role of SARS-CoV-2 N Protein in COVID-19 Disease Pathogenesis

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Known Financial Commitments (USD)

    $0

  • Funder

    University of Minnesota

  • Principal Investigator

    PhD. Qinfeng Huang

  • Research Location

    United States of America

  • Lead Research Institution

    College of Veterinary Medicine, University of Minnesota

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Led by Qinfeng Huang, PhD, research associate, Veterinary Biomedical Sciences, this study will evaluate if the nucleocapsid protein (N) protein of SARS-CoV-2 has the ability to mediate host immune suppression that can lead to high levels of virus replication to cause severe cellular inflammation and lung tissue injury. "Understanding this novel cellular mechanism of viral immune suppression can lead to a better level of understanding COVID-19 disease pathogenesis for the development of effective therapeutic and preventative measures against this highly contagious and deadly virus," said Huang.