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Angiotensin Peptide Turnover and Flux in COVID-19 Pathogenesis

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • start year

    -99

  • Known Financial Commitments (USD)

    $0

  • Funder

    University of Minnesota

  • Principal Investigator

    MD. Peter Crawford

  • Research Location

    United States of America

  • Lead Research Institution

    Medical School, University of Minnesota

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Led by Peter Crawford, MD, PhD, professor of medicine, and biochemistry, molecular biology, and biophysics; and Tim Griffin, PhD, professor of biochemistry, molecular biology, and biophysics; this study fills an unmet need by directly quantifying the responses of the angiotensin pathway in COVID-19 pathogenesis. "Our objective is to execute through a staged approach: to develop a high resolution, highly quantitative assay for angiotensin peptides in mouse plasma, and then to transition the assay to human plasma samples derived from COVID-19 clinical trials," said Crawford.