Return to homepagePandemic Pact

Identification of High-Risk COVID-19 Patients Through ACE Gene Polymorphism Detection

Grant number: unknown

Grant search

Key facts

  • Disease

    COVID-19

  • Funder

    University of Minnesota

  • Principal Investigator

    PhD. Peter Larsen

  • Research Location

    United States of America

  • Lead Research Institution

    College of Veterinary Medicine, University of Minnesota

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Peter Larsen, PhD, assistant professor in the Veterinary and Biomedical Sciences Department, is leading a study to determine if the ACE (D/D) variant can be used to predict/identify high-risk patients during the early phases of SARS-CoV-2 infection. The project's goals are to confirm if ACE (D/D) is overrepresented in patients with more severe outcomes of SARS-CoV-2 infection among their peers, and to investigate the epigenetic mechanisms underlying the effects the ACE polymorphism has on the expression of both ACE and ACE2. "The results will allow us to confirm the role that the ACE polymorphism plays in the prevalence and clinical outcome of SARS-CoV-2 infection," said Larsen. "This finding would directly inform treatment options and preventative strategies for severe COVID-19 outcomes via ACE PCR screening."