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Assessing Viral-Cellular Protein-Protein Interactions in COVID-19

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Known Financial Commitments (USD)

    $0

  • Funder

    University of Minnesota

  • Principal Investigator

    Hannah Murphy

  • Research Location

    United States of America

  • Lead Research Institution

    College of Veterinary Medicine, University of Minnesota

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The four structural proteins of human coronaviruses (CoVs), including those of the COVID-19 disease-causing SARS-CoV-2, are spike (S), membrane (M), nucleocapsid (N), and envelope (E) proteins. E protein is most enigmatic because it is the least characterized protein among them. Hannah Murphy, a graduate student from the department of veterinary biomedical sciences will study the important contribution of SARS-CoV-2 E protein to COVID-19 disease pathogenesis and its potential interactions with cellular proteins. "The high amino acid sequence identity in the important structural domains between the E proteins of the SARS-CoV-1 that caused the 2003 SARS pandemic and SARS-CoV-2 (COVID-19) suggest that these two proteins may share similar functions," said Murphy. "Published reports have shown that SARS-CoV-1 E protein can specifically interact with two key cellular proteins that can significantly contribute to the disease pathogenesis."