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Targeting Virus Assembly to Inhibit SARS-CoV-2 Infection and COVID-19 Disease

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Known Financial Commitments (USD)

    $0

  • Funder

    University of Minnesota

  • Principal Investigator

    PhD. Mizanur Rahman

  • Research Location

    United States of America

  • Lead Research Institution

    College of Veterinary Medicine, University of Minnesota

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

In order for the SARS-CoV-2 to infect humans and cause COVID-19 disease, it must be able to produce more progeny viruses in the infected cells. This process of viral assembly depends on coordinated interactions between the different viral proteins. Since this is an important process that is required for viral infection and disease pathogenesis, Postdoctoral Associate Md. Mizanur Rahman, MS, PhD, in the laboratory of Hinh Ly, MA, PhD, and Yuying Liang, MS, PhD, hypothesizes that disrupting the essential viral protein-protein interactions with antiviral drugs presents a tremendous opportunity to cripple virus replication in order to ameliorate COVID-19.